Fourteen participants (12 f; 2 m) with a median age of 32.5 (range: 26–70) yr were successively enrolled in the study. All participants were unmedicated and had no history of previous cardiac illness. Preoperative cardiac risk assessment, including ECG and chest X-ray, revealed no evidence of manifest cardiac disease.
Transthoracic TDE image acquisition and subsequent analysis was possible in all participants. Full TTS from apical four- and two-chamber views was not possible in four of 14 individuals, mainly due to poor signal/noise ratio in apical segments.
Propofol anaesthesia induction resulted in significant attenuation in blood pressure but no change in HR was observed (Table 1). TDE variables (PSV, TTD, and TTS) declined significantly, whereas TTP was unchanged (Table 1).
Limitations of the current study: As the primary objective was to evaluate LV function by measuring myocardial velocities, no LV area calculations were performed. TTS was attempted in order to form the basis for comparison with currently used methods. As noted, TTS was not possible in some patients; however, the results from 10 patients were conclusive (15.2% drop in ejection fraction) (P = 0.009). Similarly, as the study population consisted of healthy patients undergoing short-duration minor surgery no invasive pressures were coupled with TDE.
Propofol reduces tissue-Doppler markers of left ventricle function: a transthoracic echocardiographic study
1 Department of Anaesthesiology and Intensive Care
2 Department of Experimental and Clinical Research, Skejby Sygehus, Aarhus University Hospital, DK-8200 Aarhus N, Denmark
2 Department of Experimental and Clinical Research, Skejby Sygehus, Aarhus University Hospital, DK-8200 Aarhus N, Denmark