Twenty eight percent of the spontaneously active afferent fibres from sciatic nerves in the sympathectomyzed rats responded to ATP, either with an increase or with a decrease in spontaneous firing. However, none of the fibres from the sciatic nerves in the intact rats was activated by ATP.
Sympathectomy induces novel purinergic sensitivity in A afferents from sciatic nerve.
It is thought that this novel purinergic sensitivity may contribute to neuropathic paraesthesia and pain.
CHEN YONG, ZHANG YI-HONG, BIE BI-HUA, ZHAO ZHI-QI
Shanghai Institute of Physiology, Chinese Academy of Sciences
Acta Pharmacol Sin, 2000 Nov; 21 (11):1002-1004
It is thought that this novel purinergic sensitivity may contribute to neuropathic paraesthesia and pain.
CHEN YONG, ZHANG YI-HONG, BIE BI-HUA, ZHAO ZHI-QI
Shanghai Institute of Physiology, Chinese Academy of Sciences
Acta Pharmacol Sin, 2000 Nov; 21 (11):1002-1004