Increase in Kaolin-Induced Intracranial Hypertension after Decentralization of the Superior Cervical Sympathetic Ganglia in Rabbits
In fact, most of the animals in this group died in the course of the experiment, due to the excessive intracranial hypertension which was more than a tenfold increase compared to normal rabbits. It is suggested that the increased VFP following sympathetic denervation is a result of increased cerebral blood volume (vasodilation) together with increased production of cerebrospinal fluid (loss of inhibitory adrenergic nerve activity in the choroid plexuses).
L. Edvinsson, K.C. Nielsen, C. Owman, K.A. West
Departments of Histology and Neurosurgery A, University of Lund, Lund, and Neurosurgical Clinic, University Hospital, Umeå
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