Total denervation, including combined surgical and chemical sympathectomy plus vagotomy, did not reduce noradrenaline levels more than surgical sympathectomy alone, suggesting that the proportion of adrenergic fibers that derive from the vagus is quantitatively insignificant but that the vagus exerts a local control of the sympathetic stores of gastric catecholamines. Thus, surgical upper abdominal sympathectomy is the method of choice in studies of the role of the sympathetic nervous system in regulating gastric functions. Adrenaline and dopamine levels were much lower than the noradrenaline levels but showed roughly the same trends of changes after the denervations (except that chemical sympathectomy did not affect dopamine).
Scandinavian Journal of Gastroenterology, Volume 20, Issue 10 December 1985 , pages 1276 - 1280
H. Graffner a; M. Ekelund a; R. Hkanson a; E. Rosengren a
Affiliation: | a Depts. of Surgery and Pharmacology, University of Lund, Lund, Sweden |