Interactions of autonomic nervous system, pituitary-adrenocortical axis and corticotrophin and cortico-sterone in the regulation of blood sugar level in rats
Pilo, B. and Sule, J.
Division of Neuroendocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390 002 India.
Chemical sympathectomy (CSX) reduced the corticosterone concentration slightly but the ACTH level increased significantly. When sympathectomy was combined with vagotomy (CSX+VGX) an increase in both corticosterone and ACTH levels was observed. Chemical sympathectomy and adrenalectomy (CSX+ADX) also produced a maximum decrease in corticosterone level and a maximum level of ACTH. Vagotomy (VGX) alone or together with CSX or ADX produced hyperglycaemia while chemical sympathectomy alone or together with adrenalectomy produced hypoglycaemia. In conclusion it could be stated that in rats in which vagotomy was performed singly and in combination with sympathectomy, glucocorticoid secretion increased along with increased corticosterone. Chemical sympathectomy alone or together with adrenalectomy reduced the corticosterone concentration in blood together with hypoglycaemic condition. ACTH concentration by and large was more when corticosterone secretion was decreased.