Saturday, August 1, 2009

An adrenergic sensitivity in nociceptive afferents might contribute to pain and hyperalgesia

Normal inhibitory influences on pain during sympathetic arousal are compromised in the majority of patients with CRPS. The augmented vasoconstrictor response in the symptomatic limb during sympathetic arousal is consistent with adrenergic supersensitivity. An adrenergic sensitivity in nociceptive afferents might contribute to pain and hyperalgesia during sympathetic arousal in certain patients with CRPS.

Drummond PD, Finch PM, Skipworth S, Blockey P.

School of Psychology, Murdoch University, Perth, Western Australia. drummond@central.murdoch.edu.au


PMID: 11591852 [PubMed - indexed for MEDLINE