Chronotropic incompetence, an attenuated heart rate response to exercise, is a predictor of all-cause mortality in healthy populations. This association may be independent of exercise-induced myocardial perfusion defects.
Michael S Lauer, Gary S Francis, Peter M Okin, Fredric J Pashkow, et al. JAMA. Chicago:Feb 10, 1999. Vol. 281, Iss. 6, p. 524-9 (6 pp.)