Hyperglycemic responses attenuated by sympathectomy

Hyperglycemic responses to CDP-choline, choline, cytidine monophosphate and cytidine were not affected by chemical sympathectomy, but were prevented by bilateral adrenalectomy. Phosphocholine-induced hyperglycemia was attenuated by bilateral adrenalectomy or by chemical sympathectomy. These data show that CDP-choline and its metabolites induce hyperglycemia which is mediated by activation of ganglionic nicotinic receptors and stimulation of catecholamine release that subsequently activates 2-adrenoceptors.
Archives Of Physiology And Biochemistry, Volume 113, Issue 4 & 5 October 2007 , pages 186 - 201 First Published on: 03 October 2007