early lymphocytosis was absent in sympathectomized subjects

Peripheral white and red blood cell changes were studied in response to acute insulin-induced hypoglycaemia in six normal, six splenectomized and five sympathectomized (tetraplegic) subjects. The normal subjects were restudied during beta (propranolol) and beta-selective (metroprolol)  adrenergic blockade.

In the normal subjects a lymphocytosis immediately followed the acute hypoglycaemic reaction (R) with a neutrophilia 2 h later. The early lymphocytosis was absent in sympathectomized subjects and reduced under beta blockade in normal subjects, indicating mediation via an adrenergic mechanism. 

Haemoglobyn, packed cell volume and total erythrocyte count rose maximally at R in all groups except the sympathectomized subjects in vhom all parameters declined progressively from basal values. 

Peripheral blood cell changes in response to acute hypoglycaemia in man

European Journal of Clinical Investigation, Volume 13 Issue 1, Pages 33-39, 1982