Friday, January 2, 2009

Amygdala and aversive conditioning

Lesioned rats and controls were again tested for aversive conditioning to explicit and contextual cues. Rats with cell body lesions of the hippocampus showed normal suppression of drinking in the presence of the conditioned stimulus, but were severely impaired in choosing the safe environment based on contextual cues alone. These results suggest a double dissociation of the effects of amygdala and hippocampal damage on fear conditioning to explicit and contextual cues.
Department of Experimental Psychology, University of Cambridge, U.K.

Neuroscience. 1991 ;42:335-50 1832750