Monday, December 29, 2008

Adrenal Tyrosine Hydroxylase: Compensatory Increase in Activity after Chemical Sympathectomy

Destruction of peripheral sympathetic nerve endings with 6-hydroxydopamine causes a disappearance of cardiac tyrosine hydroxylase, accompanied by a twofold increase in adrenal tyrosine hydroxylase and a small increase in phenyl-ethanolanine-N-methyl transferase.
Robert A. Mueller 1, Hans Thoenen 1, and Julius Axelrod 1
Science 31 January 1969:
Vol. 163. no. 3866, pp. 468 - 469
DOI: 10.1126/science.163.3866.468

Cardiac hypertrophy accelerated by left cervical sympathectomy

Cellular and Molecular Life Sciences (CMLS)
Volume 37, Number 7 / July, 1981

Summary Cardiac hypertrophy in spontaneously hypertensive rats was accelerated by denervation of the left cervical sympathetic ganglia. Supersensitivity due to denervation may also exist in cardiac muscles.
This work was supported by a grant of the Ministry of Education for 1980.