Thursday, June 5, 2008

Norephineprine - Emotion - Memory

Dr. Walling studied the contribution of emotion to the formation of memory. Norepinephrine, a neurotransmitter released during states of heightened arousal, is considered to be the primary candidate mediating the effects of emotion on memory. Dr. Walling's study on rats provides support for the hypothesis that that short-term and long-term memory processes may be modulated by separate and distinct memory mechanisms.

Beta-blockers impair working memory

Nielson KA, Jensen RA. (1994) Beta-adrenergic receptor antagonist antihypertensive medications impair arousal-induced modulation of working memory in elderly humans. Behav Neural Biol. 62: 190-200.

beta blockers which block adrenaline can affect memory

Norepinephrine has also been implicated with memory and the beta blockers which block adrenaline can affect memory. Glutamate is important for stimulation of memory and medications which block the NMDA glutamate receptors can adversely affect memory. Serotonin can also play a role in memory. Finally, as mentioned above, the dopamine system working subcortically can affect the working memory in the frontal lobes.
Symposium 1999 – "Parkinson’s Power Across America