These results suggest that intact sympathetic nerves are necessary to maintain normal functional and structural properties of large arteries in rat. The reduction in aortic distensibility, in long-term sympathectomized rats, could have resulted from complex interactions between local aortic denervation, change in the set point of distending pressure, and changes in aortic smooth muscle tone and/or wall composition.
Auteur(s) / Author(s)
LACOLLEY P. ; GLASER E. ; CHALLNDE P. ; BOUTOUYRIE P. ; MIGNOT J.-P. ; DURIEZ M. ; LEVY B. ; SAFAR M. ; LAURENT S. ;
American journal of physiology. Heart and circulatory physiology ISSN 0363-6135 COD
1995, vol. 38, no2, pp. H407-H416 (36 ref.)