Sunday, November 30, 2008

Absence of the localized Schwartzman reaction

This investigation was undertaken to determine whether the presence of catechol amines was necessary for endotoxin to be operative in the production of a localized Schwartzman reaction. Seven rabbits were pretreated with 6–OH dopamine to produce a generalized chemical sympathectomy. An attempt was made to induce a localized Schwartzman reaction in these rabbits as well as in a control group. The rabbits in the experimental group did not develop the classical localized Schwartzman reaction, while those in the control group developed the localized Schwartzman reaction both clinically and histologically.
L. Shapiro 1 , P. Cuevas 1 , R. E. Stallard 1 , M. P. Ruben 1
1 Clinical Research Center, Boston University Medical Center, School of Graduate Dentistry, Boston, Massachusetts, USA.

Journal of Periodontal Research, Volume 9 Issue 4, Pages 207 - 210

Published Online: 30 Jun 2006