sympathectomy impairs bone resorption

the sympathetic nervous system is not involved in osteoclast precursor recruitment; but has a significant effect on resorption by inhibiting preosteoclast differentiation and disturbing osteoclast activation. These data suggest that depletion of sympathetic mediators may disturb osteogenic cell-mediated osteoclast differentiation.
M Cherruau1, P Facchinetti2, B Baroukh1, J.L Saffar1

Received 2 November 1998; received in revised form 14 May 1999; accepted 9 July 1999.

http://www.journals.elsevierhealth.com/periodicals/bon/article/PIIS8756328299002112/abstract