Regarding the modulation of autoimmunity, it was previously demonstrated that depletion of SNS transmitters by chemical sympathectomy enhances the severity of EAE (Experimental Autoimmune Encephalomyelitis.
Chelmicka-Schorr, E., M. Checincski, B. G. M. Arnason. 1988. Chemical sympathectomy augments the severity of experimental allergic encephalomyelitis. J. Neuroimmunol. 17:347.[Medline]
The Journal of Immunology, 2003, 171: 3451-3458. Copyright © 2003 by The American Association of Immunologists
Sammy Bedoui*, Sachiko Miyake*, Youwei Lin*, Katsuichi Miyamoto*,
Shinji Oki*, Noriyuki Kawamura*, Annette Beck-Sickinger ,
Stephan von Hörsten and Takashi Yamamura2,*