MARANO G. (1) ; RAMIREZ A. (2 3) ; MORI I. (2 3) ; FERRARI A. U. (2 3 4) ;
http://cat.inist.fr/?aModele=afficheN&cpsidt=1739277
Cardiovascular research ISSN 0008-6363 CODEN CVREAU
"Sympathectomy is a technique about which we have limited knowledge, applied to disorders about which we have little understanding." Associate Professor Robert Boas, Faculty of Pain Medicine of the Australasian College of Anaesthetists and the Royal College of Anaesthetists, The Journal of Pain, Vol 1, No 4 (Winter), 2000: pp 258-260
Monday, June 30, 2008
Both responses were abolished by sympathectomy
In control rats, nicotine caused a dose-dependent tachycardiac and pressor response. Both responses were abolished by sympathectomy, whereas the α-blockade left the tachycardiac response unaffected but inhibited the pressor response; the V1 vasopressin receptor blockade had no effect on either the tachycardiac or pressor response. Conclusions: We conclude that in the conscious rat: (1) the pressor response to nicotine mainly depends on peripheral a-adrenergically-mediated vasoconstriction; (2) the vasomotor effect is caused by neural rather than adrenomedullary catecholamine release; (3) the nicotine-induced increase in heart rate (and presumably cardiac output) is per se unable to raise blood pressure, and (4) the nicotine-induced release of vasopressin plays no significant role in the pressor response.
MARANO G. (1) ; RAMIREZ A. (2 3) ; MORI I. (2 3) ; FERRARI A. U. (2 3 4) ;
http://cat.inist.fr/?aModele=afficheN&cpsidt=1739277
Cardiovascular research ISSN 0008-6363 CODEN CVREAU1999, vol. 42, no1, pp. 201-205 (18 ref.)
MARANO G. (1) ; RAMIREZ A. (2 3) ; MORI I. (2 3) ; FERRARI A. U. (2 3 4) ;
http://cat.inist.fr/?aModele=afficheN&cpsidt=1739277
Cardiovascular research ISSN 0008-6363 CODEN CVREAU