Saturday, April 19, 2008

THE PREFRONTAL CORTEX is considered to be a key cortical substrate of the highest-level mental processes

THE PREFRONTAL CORTEX is considered to be a key cortical substrate of the highest-level mental processes. Yet, despite the bewildering gamut and complexity of cognitive processes that depend on the prefrontal cortex, over the last decades significant progress has been made in linking the prefrontal function with its cellular and circuit mechanisms in a field at the interface between cognitive sciences and cellular electrophysiology. A landmark paper that helped usher prefrontal research into neurophysiology is Funahashi, Bruce, and Goldman-Rakic's article published in 1989 in the Journal of Neurophysiology (3Go).

Funahashi S, Bruce CJ, and Goldman-Rakic PS. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61: 331–349, 1989 (http://jn.physiology.org/cgi/reprint/61/2/331).