NE Loss Causes Motor Impairment

Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice

K. S. Rommelfanger^*, G. L. Edwards, K. G. Freeman, L. C. Liles^*, G. W. Miller, and D. Weinshenker^*,

Departments of *Human Genetics and Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322; and Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602

Edited by Richard D. Palmiter, University of Washington School of Medicine, Seattle, WA, and approved June 25, 2007 (received for review March 27, 2007)

http://www.pnas.org/cgi/content/full/104/34/13804

NE Loss Causes Motor Impairment. We suggest two possible mechanisms for the motor impairments of Dbh–/– and LC-lesioned mice. SI Fig. 6).