Mortality in sympathectomised mice was significantly higher than that in sham operated mice following administration
of Jo-2. This result was also supported by apoptosis data in
which sympathectomised livers exhibited a significant elevation
in the number of apoptotic hepatocytes and caspase-3 activity
after Jo-2 treatment compared with sham operated livers. Moreover,
pretreatment with norepinephrine dose dependently inhibited
the hepatic sympathectomy induced increase in mortality after
Jo-2 injection. Antiapoptotic protein levels of FLICE inhibitory
protein, Bcl-xL, and Bcl-2 in the liver were significantly lower
in sympathectomised mice at one and two hours following Jo-2
treatment than in sham operated animals. In addition, interleukin
6 supplementation dose dependently suppressed the hepatic sympathectomy
induced increase in mortality after Jo-2 treatment.
The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice
Y Chida1,
N Sudo1,
A Takaki2,
C Kubo1 1 Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
2 Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Dr Y Chida
Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan