Sunday, April 13, 2008

the adrenergic system in regulation of the metabolism of the retina

Stefan M. Pojda1 Contact Information and Ryszard Brus2

(1) Department of Ophthalmology, Silesian Academy of Medicine, Francuska str. 20/24, 40-027 Katowice, Poland
(2) Department of Pharmacology, Silesian Academy of Medicine, Zabrze 8, Poland

Received: 16 April 1976

Summary Male Wistar rats were injected intraventricularly with two doses of 250 mcg of 6-hydroxydopamine (6-OHDA) in two consecutive days. Two weeks later the oxygen uptake, anaerobic glycolysis and lactic acid dehydrogenase (LDH) activity in the retina were determined. The decrease of oxygen uptake (–28 %), anaerobic glycolysis (–31 %) and LDH activity (–12 %) in rats treated with 6-OHDA in comparison to control animals was found. The possible role of the adrenergic system in regulation of the metabolism of the retina is discussed.