Wednesday, April 30, 2008

Adrenal tyrosine hydroxylase: compensatory increase in activity after chemical sympathectomy

Mueller RA, Thoenen H, Axelrod J.

Destruction of peripheral sympathetic nerve endings with 6-hydroxydopamine causes a disappearance of cardiac tyrosine hydroxylase, accompanied by a twofold increase in adrenal tyrosine hydroxylase and a small increase in phenyl-ethanolanine-N-methyl transferase. No change in adrenal catecholamine content occurs under these conditions.

Science. 1969 Jan 31;163(866):468-9

http://www.ncbi.nlm.nih.gov/pubmed/5762395