sympathetic nerves on early embryonic development and immune modulation of uterus

Role of sympathetic nerves on early embryonic development and immune modulation of uterus in pregnant mice

the CD4⁺/CD8⁺ T cells ratio significantly decreased, while the IL-2/IL-4 ratio significantly increased. These findings indicated that the activation of sympathetic nerves might be favorable to fetal survival and development during early pregnancy through influencing on immune function and decidua formation of uterus.

Yulan Dong^a, Yaoxing Chen^a, Zixu Wang^a, Jumpei Naito^b and Ji-long Chen^c
aLaboratory of Veterinary Anatomy, College of Animal Medicine, China Agricultural University, Haidian, Beijing 100094, China
^bDepartment of Animal Science, School of Sciences and Engineering, Teikyo University of Science and Technology, Yamanashi 409–0193, Japan
^cDepartment of Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Received 24 October 2005; revised 1 August 2006; accepted 2 August 2006. Available online 26 September 2006.