we have extended these studies by determining the impact of 6-hydroxydopamine (6-OHDA)-induced peripheral sympathetic denervation on these responses. C57BL/6 mice treated with 6-OHDA (200 mg/kg) were inhibited in their ability to generate primary, HSV-specific cytotoxic T lymphocytes (CTL) in response to HSV infection. sympathectomy also suppressed the activation and function of HSV-specific memory CTL (CTLm). in addition, administration of 6-OHDA resulted in a transient but substantial increase in levels of circulating corticosterone and hypothalamic fos expression.
LEO, NICOLE A.; BONNEAU, ROBERT H. a
Department of Microbiology and Immunology and Program in Neuroscience, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA
Chemical Sympathectomy Alters Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus Infection.
Source
Annals of the New York Academy of Sciences. 917:923-934, 2000.