| 1997, 190, Session F8, Poster |
| Adaptive bone remodeling in the middle ear is substance-p dependent |
| *R.A. Chole, S.P. Tinling (University of California School of Medicine, Davis, California) |
"Sympathectomy is a technique about which we have limited knowledge, applied to disorders about which we have little understanding." Associate Professor Robert Boas, Faculty of Pain Medicine of the Australasian College of Anaesthetists and the Royal College of Anaesthetists, The Journal of Pain, Vol 1, No 4 (Winter), 2000: pp 258-260
Monday, March 24, 2008
Substance-P and bone resorption
Sympathectomy is known to result in localized bone resorption in the middle ear and at other sites. (Sandhu et al 1989) Sherman & Chole (1996) found that sympathectomy induced bone resorption could be blocked by capsaicin in vivo. It was concluded that sympathectomy led to a secondary release of substance-P and then directly or indirectly to the activation of osteoclasts. Substance-P also stimulates bone resorption in vitro. It was hypothesized that substance-P is required for other types of bone remodleing, including adaptive bone remodeling.